Bone metastases most commonly respond to which therapy?

Bone metastases most commonly respond to which therapy?

• A. Radiotherapy
• B. Chemotherapy
• C. Hormone therapy
• D. Surgery

Answer: (A)

Bone metastases are typically treated most effectively with radiotherapy because these lesions are often radiosensitive and radiotherapy provides rapid local control and palliation of pain. Targeted external beam radiation delivers a high dose to the painful or structural lesion, reducing tumor activity at that site, alleviating pain, and helping prevent fracture or neurologic compromise. Chemotherapy can address systemic disease but usually doesn’t provide as reliable or quick pain relief for a single bone lesion. Hormone therapy is helpful for certain cancers that are hormone-sensitive, but its effect on established bone metastases is variable and not the primary option for immediate palliation. Surgery is reserved for stabilization, decompression, or biopsy rather than routine treatment of metastatic bone lesions.

Bone metastases are typically treated most effectively with radiotherapy because these lesions are often radiosensitive and radiotherapy provides rapid local control and palliation of pain. Targeted external beam radiation delivers a high dose to the painful or structural lesion, reducing tumor activity at that site, alleviating pain, and helping prevent fracture or neurologic compromise. Chemotherapy can address systemic disease but usually doesn’t provide as reliable or quick pain relief for a single bone lesion. Hormone therapy is helpful for certain cancers that are hormone-sensitive, but its effect on established bone metastases is variable and not the primary option for immediate palliation. Surgery is reserved for stabilization, decompression, or biopsy rather than routine treatment of metastatic bone lesions.